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  • Title: [The effectiveness of interferon-alpha therapy in Ph-positive chronic myeloid leukemia].
    Author: Bogdanov KV, Frolova OI, Marinets OV, Ogorodnikova IuS, Afanas'ev BV, Zaritskiĭ AIu.
    Journal: Vopr Onkol; 2003; 49(2):189-92. PubMed ID: 12785203.
    Abstract:
    Chronic myeloid leukemia (CML) is a hemopoietic condition caused by chromosomal translocation t(9;22)(q34;q11) or bcr-abl fusion gene. The predominant variants of bcr-abl oncogene rearrangement are b3a2 and b2a2. The present study evaluated the efficacy of interferon-a therapy of CML patients and molecular prognostic factors. Cytogenetic response and complete hematological remission were more frequent in CML b3a2 treatment with interferon-a. Moreover, after therapy, chronic phase lasted in that group (p = 0.026) much longer. Overall survival in the group was significantly longer, too (p = 0.046).
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