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  • Title: [Inhibition of the renin-angiotensin system to prevent target organ damage: the "renal continuum"].
    Author: Tislér A.
    Journal: Orv Hetil; 2003 May 04; 144(18 Suppl 1):898-901. PubMed ID: 12785234.
    Abstract:
    Similar to the atherosclerotic cardiovascular disease, primary and secondary renal diseases are also characterised by a "continuum". The "renal continuum" comprises the initial immunologic, metabolic or hemodynamic insult which, through progressive glomerular and interstitial renal damage, results in end stage renal failure. The rennin-angiotensin system plays a pivotal role in the progression of renal disease. We use diabetic nephropathy to demonstrate the clinical benefits that can be attained by administering inhibitors of the rennin-angiotensin system in more and more progressive stages of the diabetic "renal continuum". Evidence from clinical trials among diabetic patients attest to the notion that specific inhibition of the rennin-angiotensin system provides a benefit that is above what could be expected from the blood pressure lowering effects of these drugs alone.
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