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  • Title: Hemoglobin dendrimers: functional protein clusters.
    Author: Kluger R, Zhang J.
    Journal: J Am Chem Soc; 2003 May 21; 125(20):6070-1. PubMed ID: 12785833.
    Abstract:
    A cluster of cross-linked hemoglobin tetramers was prepared by conjugating active esters to amino groups of a starburst dendrimer. Comparison of oxygen-binding properties of the protein cluster to those of nonclustered species reveals an increase in affinity and a decrease in cooperativity in the cluster. The altered oxygen-binding properties are assigned to protein-protein interactions.
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