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  • Title: Rapid transport of phospholipids across the plasma membrane of Leishmania infantum.
    Author: Araújo-Santos JM, Gamarro F, Castanys S, Herrmann A, Pomorski T.
    Journal: Biochem Biophys Res Commun; 2003 Jun 20; 306(1):250-5. PubMed ID: 12788096.
    Abstract:
    The internalization of fluorescent phospholipid analogs of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), and sphingomyelin (SM) in Leishmania infantum promastigotes was studied. We observed a rapid inward redistribution of NBD-PC, -PE, and -PS across the plasma membrane at 28 and 4 degrees C. This internalization was shown to be independent of the endocytic activity of parasites. Rapid inward movement was coupled to an energy-dependent transporter because it was almost inhibited by depletion of cellular ATP and was blocked after pretreatment with N-ethylmaleimide (NEM). In contrast, NBD-SM traverses the plasma membrane by passive flip-flop. By comparing this pattern of phospholipid transbilayer movement with those known from other eukaryotic cells, candidate lipid transporters are discussed.
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