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  • Title: Variation in proton donor/acceptor pathways in succinate:quinone oxidoreductases.
    Author: Cecchini G, Maklashina E, Yankovskaya V, Iverson TM, Iwata S.
    Journal: FEBS Lett; 2003 Jun 12; 545(1):31-8. PubMed ID: 12788489.
    Abstract:
    The anaerobically expressed fumarate reductase and aerobically expressed succinate dehydrogenase from Escherichia coli comprise two different classes of succinate:quinone oxidoreductases (SQR), often termed respiratory complex II. The X-ray structures of both membrane-bound complexes have revealed that while the catalytic/soluble domains are structurally similar the quinone binding domains of the enzyme complexes are significantly different. These results suggest that the anaerobic and aerobic forms of complex II have evolved different mechanisms for electron and proton transfer in their respective membrane domains.
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