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  • Title: Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol.
    Author: Agarkov A, Uffman EW, Gilbertson SR.
    Journal: Org Lett; 2003 Jun 12; 5(12):2091-4. PubMed ID: 12790536.
    Abstract:
    [reaction: see text] Work toward the development of a bis-phosphine ligand system for the palladium-catalyzed desymmetrization of meso-diols is reported. A parallel approach using phosphine-containing amino acids and a "representational search" was taken to find a polymer-supported catalyst system. The selectivities reported are comparable to many other polymer-bound asymmetric catalysts.
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