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  • Title: Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of ecteinascidins and saframycins.
    Author: Jin W, Metobo S, Williams RM.
    Journal: Org Lett; 2003 Jun 12; 5(12):2095-8. PubMed ID: 12790537.
    Abstract:
    [reaction: see text] The asymmetric synthesis of a highly functionalized pentacyclic tetrahydroisoquinoline relevant to the ecteinascidin, saframycin, safracin, and renieramycin family of antitumor alkaloids is described.
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