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  • Title: Mitomycin C radical cation studied by pulse radiolysis.
    Author: Getoff N.
    Journal: In Vivo; 2003; 17(2):173-6. PubMed ID: 12792981.
    Abstract:
    The formation of the radical cation of mitomycin C (MMC.+) was investigated in aqueous solution by a pulse radiolysis method using SO4.- species as one electron oxidizing agent. The spectroscopic and kinetic characteristics of MMC.+ transients were determined, namely: absorption maxima at 295, 400 and 500 nm, the corresponding molar extinction coefficients are [symbol: see text] 295 = 5.63 x 10(3) dm3 mol-1 cm-1, [symbol: see text] 400 = 2.9 x 10(3) dm3 mol-1 cm-1, [symbol: see text] 500 = 2.32 x 10(3) dm3 mol-1 cm-1; the rate constant for formation of MMC.+ is k = (1.2 +/- 0.2) x 10(10) dm3 mol-1 s-1 and for decay 2k = (4.6 +/- 0.4) x 10(8) dm-3 mol-1 s-1. Based on this fact it can be assumed that not only the well-known mitomycin C radical anion (semiquinone, MMC.-) is efficiently involved in the radiotherapy process, but in a given oxidation environment the MMC.+ species could also play a role in this respect.
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