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  • Title: Signal-mediated nuclear transport in simian virus 40-transformed cells is regulated by large tumor antigen.
    Author: Feldherr CM, Lanford RE, Akin D.
    Journal: Proc Natl Acad Sci U S A; 1992 Nov 15; 89(22):11002-5. PubMed ID: 1279701.
    Abstract:
    Transformation of cultured cells with simian virus 40 (SV40), or transfection with the early region of the SV40 genome, causes a significant increase in both the rate of signal-mediated nuclear transport and the functional size of the transport channels (located in the pore complexes). By microinjecting purified large tumor (T) antigen into the cytoplasm of murine BALB/c 3T3 cells, we have demonstrated that this protein alone can account for the increase in transport capacity. The T antigen-dependent changes can be partially inhibited by cycloheximide and require a functional nuclear localization sequence. Although necessary, the nuclear localization sequence by itself cannot produce the observed variations in nuclear permeability and presumably function in a "helper" capacity, in association with another, as yet unidentified domain.
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