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  • Title: Combined systemic and intrapleural treatment of Aspergillus pulmonary empyema after invasive aspergillosis.
    Author: Baquero-Artigao F, García-Miguel MJ, Hernández F, Hernández N, del Castillo F.
    Journal: Pediatr Infect Dis J; 2003 May; 22(5):471-3. PubMed ID: 12797318.
    Abstract:
    A 12-year-old immunocompromised boy was hospitalized because of invasive aspergillosis with lung and central nervous system involvement. He was treated with surgery and liposomal amphotericin B, but he developed a pulmonary empyema and a bronchopleural-cutaneous fistula. A catheter was placed through the fistula, and amphotericin B (up to 50 mg in 10 ml of 5% dextrose) was instilled daily into the pleural cavity for 45 days. Treatment was well-tolerated, and the empyema resolved completely, with no evidence of recurrence after 2 years of follow-up.
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