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  • Title: Pyruvate kinase: current status of regulatory and functional properties.
    Author: Muñoz ME, Ponce E.
    Journal: Comp Biochem Physiol B Biochem Mol Biol; 2003 Jun; 135(2):197-218. PubMed ID: 12798932.
    Abstract:
    Pyruvate kinase (PK) is a key enzyme for the glycolytic pathway and carbon metabolism in general. On the basis of the relevance and enormous diverse properties of this enzyme, this paper describes the results of a current and extensive review that determines the sites of conservation and/or difference in PK sequences, and the differences in the functional and regulatory properties of the enzymes. An alignment and analysis of 50 PK sequences from different sources and a phylogenetic tree are presented. This analysis was performed with reference to crystallographically characterized PK principally from E. coli, cat and rabbit muscle. A number of attributes of the enzyme that make it of particular interest in biomedicine and industry are also discussed.
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