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  • Title: An antibody against a CFTR-derived synthetic peptide, incorporated into living submandibular cells, inhibits beta-adrenergic stimulation of mucin secretion.
    Author: Mills CL, Pereira MM, Dormer RL, McPherson MA.
    Journal: Biochem Biophys Res Commun; 1992 Nov 16; 188(3):1146-52. PubMed ID: 1280131.
    Abstract:
    An antibody raised against a peptide in the first nucleotide-binding domain (NBD) of CFTR [1], incorporated into intact rat submandibular acini by hypotonic swelling, inhibited beta-adrenergic stimulated mucin secretion, without affecting cyclic AMP rise. The data are the first to show that a CFTR-antibody-containing cell results in defective stimulation of mucin secretion, as is seen in CF cells, and that this can be reversed by an excessive increase in cyclic AMP.
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