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  • Title: Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea.
    Author: Politi M, Braca A, De Tommasi N, Morelli I, Manunta A, Battinelli L, Mazzanti G.
    Journal: Planta Med; 2003 May; 69(5):468-70. PubMed ID: 12802733.
    Abstract:
    Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8 beta-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7 beta-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.
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