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  • Title: Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia.
    Author: Mohite U, Pathare A, al Kindi S, Hiwase D, Vadakkepat N, Knox-Macaulay H.
    Journal: Haematologia (Budap); 2002; 32(4):495-9. PubMed ID: 12803124.
    Abstract:
    We report an unusual case of a 40-year-old female patient with a severe case of direct Coombs positive haemolytic anaemia, moderate hepatomegaly and marked splenomegaly. Her initial response to steroids was transient and was rapidly followed by a relapse. Therefore, she underwent splenectomy both as a therapeutic measure and to rule out an underlying lymphoproliferative disorder. Histopathological examination of the excised spleen, as well a liver biopsy, revealed extensive extramedullary haematopoiesis, while significant marrow fibrosis was noted in a trephine biopsy sample. These findings confirmed the concomitant diagnosis of agnogenic myeloid metaplasia with myelofibrosis.
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