These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0.
    Author: Ben Jelloun-Dellagi S, Dellagi K, Burger D, Ben Younes-Chennoufi A, Hentati FF, Steck A, Ben Hamida M.
    Journal: Ann Neurol; 1992 Nov; 32(5):700-2. PubMed ID: 1280408.
    Abstract:
    The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient.
    [Abstract] [Full Text] [Related] [New Search]