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  • Title: Cutaneous granulomas as the first manifestation of Hodgkin's disease.
    Author: Macaya A, Servitje O, Moreno A, Peyrí J.
    Journal: Eur J Dermatol; 2003; 13(3):299-301. PubMed ID: 12804995.
    Abstract:
    We report the case of a 64-year-old male in whom fever, cutaneous rash and hepatomegaly were the first manifestations of Hodgkin disease (HD). Histologically a dense lymphohistiocytic infiltrate with a granulomatous pattern was found in the skin infiltrate. A computed tomography scan revealed hepatosplenomegaly and a small retroperitoneal lymphadenopathy. An hepatic percutaneous biopsy showed a granulomatous infiltration with typical Reed-Sternberg cells. Cutaneous manifestations of HD are briefly reviewed. The authors underline that granulomatous infiltration of the skin as the first manifestation of lymphoma is a very rare feature. We also discuss the possible pathogenic mechanisms of skin granulomas.
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