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  • Title: Signal transducer and activator of transcription-3 activation is mediated by N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel during cerebral ischemia in rat hippocampus.
    Author: Li H, Zhang Q, Zhang G.
    Journal: Neurosci Lett; 2003 Jul 10; 345(1):61-4. PubMed ID: 12809989.
    Abstract:
    It has been proved that signal transducer and activator of transcription-3 (STAT3) is expressed and activated following cerebral ischemia/reperfusion in cortex and striatum. Here we investigated the changes in tyrosine phosphorylation and DNA-binding activity of STAT3 in hippocampus in a four-vessel occlusion model of Sprague-Dawley rats. Phospho-STAT3 (in cytoplasm) was enhanced from 5 min and reached its peak level at 10 min of ischemia. While in nucleus, phospho-STAT3 increased from 10 min and then peaked at 30 min of ischemia. Concomitantly, DNA-binding activity of STAT3 demonstrated a similar rule in nucleus extracts. The increased tyrosine phosphorylation and DNA-binding activity of STAT3 in nucleus were blocked by ketamine, an N-methyl-D-aspartate receptor antagonist, or by nifedipine, a L-type voltage-gated Ca(2+) channel (L-VGCC) antagonist. These results illustrated that the ionotropic glutamate receptor and L-VGCC are important in mediating STAT3 activation during severe cerebral ischemia.
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