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  • Title: CARD15/NOD2 analysis in rheumatoid arthritis susceptibility.
    Author: Ferreirós-Vidal I, Barros F, Pablos JL, Carracedo A, Gómez-Reino JJ, Gonzalez A.
    Journal: Rheumatology (Oxford); 2003 Nov; 42(11):1380-2. PubMed ID: 12810925.
    Abstract:
    OBJECTIVE: To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA). METHODS: The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls. RESULTS: Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%). CONCLUSION: There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.
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