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  • Title: Checkpoint mediators: relaying signals from DNA strand breaks.
    Author: Canman CE.
    Journal: Curr Biol; 2003 Jun 17; 13(12):R488-90. PubMed ID: 12814569.
    Abstract:
    The recently identified checkpoint mediator MDC1 facilitates recruitment of DNA repair proteins to damaged sites and establishment of the intra-S-phase cell-cycle checkpoint. Increasing evidence suggests that proteins like MDC1 provide the framework necessary for transducing signals from DNA double-strand breaks.
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