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  • Title: Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB.
    Author: Dierick JF, Wenders F, Chainiaux F, Remacle J, Fisher AB, Toussaint O.
    Journal: Biogerontology; 2003; 4(3):125-31. PubMed ID: 12815311.
    Abstract:
    In this work, stable overexpression of peroxiredoxin VI was generated in WI-38 human diploid fibroblasts using a retrovirus-mediated transfection system. Estimation of cell survival showed that peroxiredoxin VI provides a significant protection against tert-butylhydroperoxide- or UVB-caused cytotoxicity. No protection was found against ethanol- or H(2)O(2)-caused cytotoxicity. These effects are correlated with the known functions of Prx VI.
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