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  • Title: Asymmetric total synthesis of pseurotin A.
    Author: Hayashi Y, Shoji M, Yamaguchi S, Mukaiyama T, Yamaguchi J, Kakeya H, Osada H.
    Journal: Org Lett; 2003 Jun 26; 5(13):2287-90. PubMed ID: 12816430.
    Abstract:
    The asymmetric total syntheses of pseurotin A and 8-O-demethylpseurotin A have been accomplished. Key reactions are a NaH-promoted intramolecular cyclization of an alkynylamide to form a gamma-lactam, an aldol reaction of a benzylidene-substituted ketone, and the late-stage introduction of the benzoyl group by a selective oxidation of a benzylidene moiety with dimethyldioxirane (DMD). [reaction: see text]
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