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  • Title: Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers.
    Author: du Laney TV, Cherry RS, Coppinger JA, Truskey GA.
    Journal: Biotechnol Prog; 1992; 8(6):572-5. PubMed ID: 1282019.
    Abstract:
    The mitochondria and actin fibers of 3T3 fibroblasts cultured on microcarriers in spinner flasks were visualized using fluorescent stains. In contrast to cells grown on planar surfaces under static or steady laminar flow conditions, cells exposed to higher levels of turbulent agitation do not form actin stress fibers. Greater agitation also leads to a more diffuse appearance of the mitochondria and a wider distribution of them throughout the cytoplasm. This response may indicate damaged mitochondria, as similar results have been reported for chemical toxins.
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