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  • Title: Interleukin 1 receptor antagonist (IL-1RA) polymorphism in women with cervical cancer.
    Author: Mustea A, Sehouli J, Könsgen D, Stengel D, Sofroni D, Lichtenegger W.
    Journal: Anticancer Res; 2003; 23(2A):1099-102. PubMed ID: 12820354.
    Abstract:
    BACKGROUND: Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer. MATERIALS AND METHODS: In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR. RESULTS: The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age. CONCLUSION: This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.
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