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  • Title: [A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis].
    Author: Liu W, Zhang CY, Wu XM, Tian L, Li CZ, Zhao QM, Zhang PH, Yang SM, Yang H, Zhang XT, Cao WC.
    Journal: Zhonghua Liu Xing Bing Xue Za Zhi; 2003 May; 24(5):389-92. PubMed ID: 12820934.
    Abstract:
    OBJECTIVE: To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis. METHODS: Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package. RESULTS: A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253). CONCLUSION: The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
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