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  • Title: Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome.
    Author: Zachwieja J, Bobkowski W, Dobrowolska-Zachwieja A, Zaniew M, Maciejewski J.
    Journal: Med Sci Monit; 2003 Jun; 9(6):CR235-9. PubMed ID: 12824952.
    Abstract:
    BACKGROUND: The aim of the present study was to estimate the total antioxidant status (TAS) and main antioxidant enzyme activity in children with nephrotic syndrome (NS). MATERIAL/METHODS: The study was carried out in a group of 82 children with NS, age 4-16 years (mean 7.4). Of these, 59 with a first episode formed group I, and 23 children in remission (>6 months, with no immunosuppressive treatment) formed group II. TAS was estimated using the two-reagent Randox Total Antioxidant Status test in plasma. RESULTS: TAS was significantly reduced in group I compared to controls (0.77+/-0.14 mmol/l vs. 1.18+/-0.42 mmol/l; p<0.001). The TAS level was more reduced in those patients with higher total cholesterol (TChol) and low density lipoproteins cholesterol (LDL-cholesterol). In children from group I the activity of glutathione reductase (GR) was lower than in the controls (8.10+/-2.40 U/g Hb vs. 10.55+/-3.81 U/g Hb, p<0.001) and similarly the activity of glutathione peroxidase (GPX) was lower in group I compared to controls (28.65+/-6.99 U/g Hb vs. 33.84+/-13.11 U/g Hb, p=0.010). There was no significant difference in superoxide dismutase (SOD) activity between the 3 groups. CONCLUSIONS: Reduced antioxidant activity may be related to lipid abnormalities in NS.
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