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  • Title: Efficacy of various concentrations of coumaphos to control adult, nymphal, and larval stages of an organophosphate-resistant strain of Boophilus microplus on infested cattle.
    Author: Davey RB, George JE, Miller RJ.
    Journal: Am J Vet Res; 2003 Jun; 64(6):684-9. PubMed ID: 12828252.
    Abstract:
    OBJECTIVE: To evaluate the efficacy of coumaphos, an organophosphate (OP) acaricide, at concentrations up to 2 times higher than the highest concentration required by the US Eradication Program against all stages of an OP-resistant strain of Boophilus microplus in experimentally infested cattle. ANIMALS: 16 tick-naïve 200-kg female Hereford calves. PROCEDURE: Four groups of cattle (4 calves/group) were all infested with Boophilus ticks 3 times before treatment. Each group was treated with coumaphos as follows: group 1, at 0.165% active ingredient (AI); group 2, at 0.299% AI; group 3, at 0.566% AI; and group 4, not treated. Following treatment, ticks were collected for 21 days. Ticks collected 1 to 7, 8 to 14, and 15 to 21 days after treatment were considered adults, nymphs, and larvae, respectively, at time of treatment. RESULTS: Overall control at 0.165, 0.299, and 0.566% AI was 52.9, 75.8, and 89.7%, respectively. Control of adults ranged from 4.3% at 0.165% AI to 73.5% at 0.566% AI. Control of nymphs ranged from 60.6% at 0.165% AI to 97.3% at 0.566% AI. Control of larvae was > 98% at all coumaphos concentrations. CONCLUSIONS AND CLINICAL RELEVANCE: All coumaphos concentrations failed to provide acceptable control for use in the US Eradication Program against OP-resistant ticks. Treatment was least effective against adults and most effective against larvae. Even at 0.566% AI (2 times higher than required by the US Eradication Program), ticks were not eradicated, placing the United States at risk from dispersing cattle harboring viable ticks to uninfested areas.
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