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  • Title: New cytotoxic indolic metabolites from a marine Streptomyces.
    Author: Sánchez López JM, Martínez Insua M, Pérez Baz J, Fernández Puentes JL, Cañedo Hernández LM.
    Journal: J Nat Prod; 2003 Jun; 66(6):863-4. PubMed ID: 12828477.
    Abstract:
    Three new cytotoxic 3,6-disubstituted indoles (1-3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was separated from a Mexican marine invertebrate, and their structures established by analysis of NMR and mass spectral data. GI(50) values for 1 and 2 in cytotoxic bioassays against a panel of 14 different tumor cell lines were estimated at micromolar range, while compound 3 showed no activity in the same assays.
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