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  • Title: The gp120 glycoprotein of HIV-1 binds to sulfatide and to the myelin associated glycoprotein.
    Author: van den Berg LH, Sadiq SA, Lederman S, Latov N.
    Journal: J Neurosci Res; 1992 Dec; 33(4):513-8. PubMed ID: 1282933.
    Abstract:
    We investigated the binding of the gp120 glycoprotein of the human immunodeficiency virus (HIV-1) to neural glycolipids and glycoproteins by ELISA. The gp120 protein bound to sulfatide (GalS), a sulfated glycolipid autoantigen implicated in sensory neuritis, and to the myelin associated glycoprotein (MAG), an autoantigen in demyelinating neuropathy. Binding of gp120 to MAG was inhibited by the HNK-1 antibody, which recognizes a sulfated glucuronic acid epitope, suggesting that the interaction involves carbohydrate determinants. Sulfatide and MAG are potential receptors for gp120 in peripheral nerve and may have a role in the neuropathy associated with HIV-1 infection.
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