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  • Title: Diagnosis of enterovirus infection in the first 2 months of life by real-time polymerase chain reaction.
    Author: Verboon-Maciolek MA, Nijhuis M, van Loon AM, van Maarssenveen N, van Wieringen H, Pekelharing-Berghuis MA, Krediet TG, Gerards LJ, Fleer A, Diepersloot RJ, Thijsen SF.
    Journal: Clin Infect Dis; 2003 Jul 01; 37(1):1-6. PubMed ID: 12830402.
    Abstract:
    During summer and fall, enterovirus infections are responsible for a considerable proportion of hospitalizations of young infants. We prospectively studied the incidence of enterovirus infections via real-time polymerase chain reaction (PCR) in blood, feces, and cerebrospinal fluid samples from infants <or=60 days old who had received a clinical diagnosis of sepsis. Forty-five patients were included: 19 were admitted to the pediatric wards of 2 general hospitals, and 26 had been hospitalized since birth in the neonatal intensive care unit (NICU) of a tertiary care hospital. None of the NICU patients developed enteroviral disease. In contrast, an enterovirus was detected in 11 (58%) of the patients admitted to the 2 general hospitals, 10 of whom (53%) showed evidence of systemic infection. Enterovirus infections are an important cause of sepsis in infants admitted to the hospital. Real-time PCR in serum was a rapid and sensitive method for diagnosis of enterovirus infection.
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