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  • Title: Abnormal distribution of desmin and vimentin in myofibers in adult onset myotubular myopathy.
    Author: Misra AK, Menon NK, Mishra SK.
    Journal: Muscle Nerve; 1992 Nov; 15(11):1246-52. PubMed ID: 1283202.
    Abstract:
    We report, for the first time, muscle immunocytochemical studies in sporadic, adult onset myotubular myopathy (SAOMM), which show intramyofibrillar central, perinuclear desmin and vimentin. This pattern was absent in a normal control and in myofibers with increased internal nuclei associated with denervation and myotonic muscular dystrophy (MyD). These findings resemble those reported in 8- to 15-week-old human fetal myotubes and myofibers of infantile MM, implying a possible regression of intermediate filaments of adult myofibers to an early developmental phase in SAOMM.
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