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  • Title: [Detection of clonal immunoglobulin rearrangements in paraffin embedded tissues by PCR].
    Author: Zhao M, Küppers R, Hansmann ML, Lorenzen J, Rajewsky K, Fischer R.
    Journal: Verh Dtsch Ges Pathol; 1992; 76():243-7. PubMed ID: 1283268.
    Abstract:
    A polymerase chain reaction based method was established using immunoglobulin VH and VK gene rearrangements as markers to detect clonal B cell populations in paraffin embedded sections. Family specific VH and VK primers are used in separate reactions together with the corresponding J primers to amplify rearranged VH and VK genes from genomic DNA. This allows to distinguish clonal from polyclonal B cell populations in most of the cases. The method may be helpful in routine diagnosis of B cell NHL and some morphological and immunohistochemical difficult cases.
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