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  • Title: Calcium channel blocker-like action of reserpine in smooth muscle.
    Author: Satoh T, Moriyama T, Kuriki H, Karaki H.
    Journal: Jpn J Pharmacol; 1992 Nov; 60(3):291-3. PubMed ID: 1283423.
    Abstract:
    The effect of reserpine on vascular and intestinal smooth muscles was examined. In these muscles, reserpine inhibited the high K(+)-induced contraction, and this inhibitory effect was antagonized by the increase in external Ca2+ concentration and also by a Ca2+ channel activator, Bay k8644. In rabbit aorta, increases in cytosolic Ca2+ level and muscle tension due to high K+ were inhibited in parallel by reserpine. These results suggest that reserpine inhibits L-type Ca2+ channels to inhibit smooth muscle contraction.
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