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  • Title: Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.
    Author: Sano A, Yamakoshi J, Tokutake S, Tobe K, Kubota Y, Kikuchi M.
    Journal: Biosci Biotechnol Biochem; 2003 May; 67(5):1140-3. PubMed ID: 12834296.
    Abstract:
    To confirm the absorption of proanthocyanidin (PA) into the human body, four healthy adults were administered 2.0 g of PA-rich grape seed extract (GSE). Blood were drawn before intake and 2 h after intake. Through the enzymatic treatment of sulfatase and beta-glucuronidase, blood samples were analyzed by HPLC coupled with mass-spectrometry (LC/MS). Procyanidin B1 [epicatechin-(4beta-->8)-catechin] was detected in human serum 2 h after intake. Its concentration was 10.6 +/- 2.5 nmol/l.
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