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  • Title: The activation of 5-HT(3) receptors evokes GABA release in the spinal cord.
    Author: Kawamata T, Omote K, Toriyabe M, Yamamoto H, Namiki A.
    Journal: Brain Res; 2003 Jul 18; 978(1-2):250-5. PubMed ID: 12834922.
    Abstract:
    We carried out experiments using a microdialysis method to determine whether activation of 5-HT(3) receptors increases the concentration of GABA in the dorsal horn of the spinal cord. Intrathecal perfusion of a selective 5-HT(3) receptor agonist, 1-phenylbiguanide (0.3, 1.0, and 3.0 mM) dose-dependently, increased GABA concentration, while concentrations of glutamate and glycine were not changed. The concentration of aspartate was increased only by 3.0 mM of 1-phenylbiguanide. Our results have provided direct evidence that activation of 5-HT(3) receptors evokes GABA release in the spinal dorsal horn, possibly producing analgesia.
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