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  • Title: Modulatory effect of copper on nonenzymatic antioxidants in freshwater fish Channa punctatus (Bloch.).
    Author: Parvez S, Sayeed I, Pandey S, Ahmad A, Bin-Hafeez B, Haque R, Ahmad I, Raisuddin S.
    Journal: Biol Trace Elem Res; 2003; 93(1-3):237-48. PubMed ID: 12835505.
    Abstract:
    Effect of the low level of copper exposure on nonenzymatic antioxidants was studied in a freshwater fish Channa punctatus (Bloch.). Fish were exposed to cupric chloride at the concentration of 10 ppb for 4 wk (28 d) in a static culture condition. Copper significantly (p < 0.001) increased the serum ceruloplasmin level and total iron-binding capacity. A significant (p < 0.05) increase in reduced glutathione level was recorded in all of the tissues. With regard to nonprotein thiols, copper decreased their level in the liver, but increased it in the gill. The protein-bound thiols remained unaltered except for an increase in the liver. Metallothionein (MT) induction was observed in liver only. Copper exposure had no significant effect on the ascorbic acid level and induced no lipid peroxidation over control values. It is suggested that by modulating the ceruloplasmin level, copper indirectly protects the fish, as it facilitates conversion of pro-oxidant iron to nonoxidant iron. It also induces an array of antioxidants that may be beneficial to fish in the case of oxidative stress resulting from chemical pollutants.
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