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  • Title: Numerous SP-positive pyramidal neurons in cat neocortex are glutamate-positive.
    Author: Conti F, Fabri M, Minelli A.
    Journal: Brain Res; 1992 Dec 18; 599(1):140-3. PubMed ID: 1283558.
    Abstract:
    An immunocytochemical technique that allows visualization of two antigens in the same neuron was used to verify the possibility that some neocortical pyramidal neurons contain both glutamate (Glu) and substance P (SP) immunoreactivity. The results show that a large fraction of SP-positive pyramidal neurons are also Glu-positive, and indicate that in a small population of cortical neurons a fast excitatory synaptic transmitter and a slow peptidic modulator coexist.
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