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  • Title: Surface plasmon resonance mass spectrometry: recent progress and outlooks.
    Author: Nedelkov D, Nelson RW.
    Journal: Trends Biotechnol; 2003 Jul; 21(7):301-5. PubMed ID: 12837614.
    Abstract:
    The combination of surface plasmon resonance (SPR) and mass spectrometry (MS) has created a unique approach to protein investigations. Surface plasmon resonance is used to quantify interactions between proteins and surface-immobilized ligands, and MS is used to determine the structural features of the bound proteins. Recent progress in SPR-MS includes improved methods and operations, increased limits of detection, multi-protein analysis and protein-complex delineation. With the subsequent design of SPR protein arrays, SPR-MS is expected to enter into the field of high-throughput protein interaction discovery and miniaturized diagnostics.
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