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  • Title: [Characteristics of auditory brainstem responses and the development of the bundles of inner and outer hair cell of newborn mice].
    Author: Li C, Wu L, Chi F.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2003 Apr; 17(4):224-5. PubMed ID: 12838867.
    Abstract:
    OBJECTIVE: To investigate the characteristics of the ABR and discuss the development of the bundles of inner and outer hair cell. METHOD: Testing the ABR of newborn mice, the response threshold of ABR, latency of wave I were examined. Using scanning electron microscopy, the development of the bundles of inner and outer hair cell of postnatal mice were studied. RESULT: (1) The average response threshold of ABR was (57.5 +/- 2) dB of 15-day-old mice. The average response threshold of ABR was (37.5 +/- 1) dB of 17-day-old, 21-day-old and 28-day-old mice. There was no difference in wave form. (2) The latencies of wave I of ABR differed significantly (P < 0.05) in 15-day-old mice and 17-day-old mice, 21-day-old mice and 28-day-old mice. The latencies of wave I of ABR didn't differ significantly (P > 0.05) in 17-day-old mice and 21-day-old mice and 28-day-old mice. (3) The development of the bundles is interpreted as a five-step process. CONCLUSION: The stable ABR appeared at the mice of 17 days. The response threshold goes down gradually. The latency of wave I becomes shorter and shorter. The bundles of inner and outer hair cell of newborn 17-day-old mice get maturity.
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