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  • Title: [Effectiveness of local prostaglandin instillations in tubal pregnancy in relation to preoperative beta-HCG level].
    Author: Spitzer D, Steiner H, Batka M, Staudach A.
    Journal: Z Geburtshilfe Perinatol; 1992; 196(6):244-6. PubMed ID: 1283931.
    Abstract:
    33 patients with tubal pregnancy and beta-HCG level less than 2500 mIU/ml were treated with local, laparoscopic Prostaglandin-injection. Re-operation was not necessary and beta-HCG fell to undetectable levels in 73% (p = 0.05). Serial beta-HCG correlated poorly with outcome. In patients with an increasing beta-HCG success was limited to 55% (p = 0.59). In contrast patients with falling or stable beta-HCG values had success rates of 85.7% (p = 0.22) and 83.5% (p = 0.30) respectively. Our data suggests there may be a clinical advantage to the use of prostaglandin-injection for the conservative management of early ectopic pregnancy. However the utility of preoperative serial beta-HCG values in predicting success showed a trend, without reaching statistical significance.
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