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  • Title: [Autoantibodies against the beta 1-adrenergic receptor in myocarditis and dilated cardiomyopathy: localization of two epitopes].
    Author: Wallukat G, Morwinski R, Magnusson Y, Hoebeke J, Wollenberger A.
    Journal: Z Kardiol; 1992; 81 Suppl 4():79-83. PubMed ID: 1283934.
    Abstract:
    Sera of patients with myocarditis and dilated cardiomyopathy contain stimulatory autoantibodies directed specifically against the beta 1-adrenergic receptor. The binding of the antibodies could be localized to either the first or the second extracellular loop of the beta 1-adrenoceptor. In 73% of the cases investigated the antibodies recognized the second extracellular loop. The agonistic effects of the antibodies were abolished by beta-adrenergic antagonists. Furthermore, the antagonists were able to remove the antibodies from their binding sites.
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