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  • Title: Novel enzymatic synthesis of 4-O-cinnamoyl quinic and shikimic acid derivatives.
    Author: Armesto N, Ferrero M, Fernández S, Gotor V.
    Journal: J Org Chem; 2003 Jul 11; 68(14):5784-7. PubMed ID: 12839485.
    Abstract:
    The first direct synthesis of 4-O-cinnamoyl derivatives of quinic and shikimic acids were accomplished by regioselective esterification with Candida antarctica lipase A. For hydrocinnamic esters, enzymatic transesterification with vinyl esters gave excellent yields. However, more reactive acylating agents such as anhydrides were used to synthesize cinnamic derivatives of both acids. An inhibitory effect was observed with this lipase for p-methoxy, p-hydroxy, and p-acetoxy vinyl ester and anhydride derivatives (coumarate and ferulate derivatives).
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