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  • Title: Recurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: a comparison with Graves' disease.
    Author: van Soestbergen MJ, van der Vijver JC, Graafland AD.
    Journal: J Endocrinol Invest; 1992 Dec; 15(11):797-800. PubMed ID: 1283983.
    Abstract:
    The chance of permanent remission after prolonged drug therapy was investigated in 41 patients with toxic multinodular goiter. For purposes of comparison a group of 41 patients with Graves' disease was also studied. After euthyroidism was achieved all patients received a combination of thionamide and thyroxine for at least 12 months. The minimum follow-up period was 2 yr. Relapse of thyrotoxicosis occurred in 95.1% of patients with toxic multinodular goiter and 34.1% of patients with Graves' disease (p < 0.001). It is concluded that for patients with toxic multinodular goiter early radioiodine therapy or surgery is preferred since prolonged drug therapy seldom produces permanent remission.
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