These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A highly efficient catalytic system for cross-coupling of aryl chlorides and bromides with malononitrile anion by palladium carbene complexes.
    Author: Gao C, Tao X, Qian Y, Huang J.
    Journal: Chem Commun (Camb); 2003 Jun 21; (12):1444-5. PubMed ID: 12841283.
    Abstract:
    Six imidazolium chlorides (1-6) as precursors of 1,3-diaryl substituted N-heterocyclic carbene ligands were synthesized and evaluated in palladium-catalyzed cross-coupling reactions of aryl chlorides and bromides with malononitrile in the presence of NaH. Among them, 1,3-bis(2,4,6-triethylphenyl)imidazolium chloride (5) and 1,3-bis(2,4,6-triisopropylphenyl)imidazolium chloride (6) are novel. The catalytic system combining Pd(0) with imidazolium salts 4, 5 and 6 with bulky aryl groups in pyridine is found to be superior over others and afforded alpha-arylmalononitriles in high yields when employing a wide variety of substrates.
    [Abstract] [Full Text] [Related] [New Search]