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  • Title: [Acute respiratory distress syndrome due to pneumonitis following intrathecal methotrexate administration].
    Author: Le Guillou F, Dominique S, Dubruille V, Contentin N, Tilly H, Nouvet G.
    Journal: Rev Mal Respir; 2003 Apr; 20(2 Pt 1):273-7. PubMed ID: 12844025.
    Abstract:
    INTRODUCTION: Methotrexate, given orally or systemically, is associated with pneumonitis in 7% of cases. CASE REPORT: This case report describes acute respiratory distress syndrome, due to diffuse pneumonitis, in a patient with malignant non-Hodgkin's lymphoma being treated with combination chemotherapy which included doxorubicin, cyclophosphamide, bleomycin, vindesin and intrathecal methotrexate with G-CSF (filgrastine- Neupogen). The clinical course, the lack of an identifiable infectious agent and the complete response to corticosteroids suggested a drug-induced cause. After ruling out the other chemotherapy agents, methotrexate was considered to be the causal agent. The unusual feature of this case was that pneumonitis developed after intrathecal administration of methotrexate. CONCLUSION: Methotrexate-associated respiratory complications can occur with whichever route the drug is administered.
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