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  • Title: The role of protein kinase C and its effect on GHRH in the regulation of hormone secretion by somatotrophinomas.
    Author: Liu K, Liu Q, Bai X, Lei T, Xue D.
    Journal: J Tongji Med Univ; 2000; 20(1):16-9. PubMed ID: 12845746.
    Abstract:
    Phorbol ester-induced release of growth hormone (GH) and prolactin (PRL) from human somatotrophic tumors was examined in vitro. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). In contrast, staurosporine exerted a variable inhibitory effect on GH release. There was no correlation between such effects and gsp mutations. The findings suggested that TPA doesn't act directly through cAMP signal transduction system.
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