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  • Title: Synthesis and biological activity of certain novel derivatives of 1H-pyrrolo[1,2-c][1,3]thiazine.
    Author: Jagodziński TS, Wesołowska A, Jagodzińska E, Rump S.
    Journal: Acta Pol Pharm; 2003; 60(1):67-73. PubMed ID: 12848370.
    Abstract:
    The reaction of 2-(beta-hydroxyethyl)-pyrrolidine with isothiocyanates gave rise to the formation of thiourea derivatives which cyclised on refluxing in hydrobromic acid to yield N-(3,4,4a,5,6,7-hexahydro-1H-pyrrolo[1,2-c][1,3]thiazin-1-ylidene)-aryl(alkyl)amines. The results of preliminary pharmacological screening are presented.
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