These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Alteration of alpha-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate.
    Author: Youssef R, Malaisse WJ, Courtois P, Sener A.
    Journal: Int J Mol Med; 2003 Aug; 12(2):199-200. PubMed ID: 12851717.
    Abstract:
    A sufficient availability of the bicarbonate anion is required to allow a normal process of glucose-stimulated insulin release. Thus, both the removal of extracellular bicarbonate and the inhibition of carbonic anhydrase by acetazolamide suppress the insulinotropic action of glucose. In the present study, a comparable situation is documented in rat parotid cells. Thus, the absence of extracellular bicarbonate is shown to decrease by about 50% basal alpha-amylase secretion, as well as carbamylcholine- and isoproterenol-stimulated alpha-amylase output, without suppressing the enhancing action of the two agents. It is proposed, therefore, that the HCO3-anion participates in the secretory sequence at sites distal to the identification of secretagogues in both endocrine and exocrine cells.
    [Abstract] [Full Text] [Related] [New Search]