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  • Title: [Replication of animal model and pathological study of delayed multiple organ dysfunction syndrome in mice].
    Author: Sun Y, Lu JY, Wang XH, Hu S, Yang Y, Tong X.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2003 Jan; 15(1):15-8. PubMed ID: 12852807.
    Abstract:
    OBJECTIVE: To replicate a model of delayed multiple organ dysfunction syndrome (MODS) in mice. METHODS: Kunming mice of 6-8 week age were randomly divided into normal control group and experimental group. They were sacrificed on days 0 to 2, days 3 to 7, days 8 to 12. Symptoms and signs, survival rate, organ function parameters and pathological changes in main organs were observed in mice of all groups. RESULTS: Eight days after zymosan administration, animals showed MODS-like changes. Plasma level of alanine aminotransferase(ALT), blood urea nitrogen(BUN) and creatinine(Cr) were increased and severe pathological lesions were observed in tissues of the lung, liver, heart, kidney and gut, etc. CONCLUSION: A delayed model of MODS is replicated in mice by intraperitoneal injection of zymosan.
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