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  • Title: Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry.
    Author: Schürer M, Amschler S, Schulz HU, Schäfer HF.
    Journal: Arzneimittelforschung; 2003; 53(5):307-13. PubMed ID: 12854357.
    Abstract:
    A specific, sensitive and precise method for the simultaneous determination of spirapril (CAS 94841-17-5) and spiraprilat (CAS 83602-05-5) in human plasma is described. The method involves the use of enalapril as internal standard, solid-phase extraction, derivatization and capillary gas chromatography with mass sensitive detection. The working range is from 2.5 to 500 micrograms/l for spirapril and spiraprilat, respectively. Data demonstrating the precision and accuracy of the analytical method are given. Moreover, data concerning freeze-thaw stability, long-term stability of frozen samples, short-term stability of thawed samples, and stability of the extracts in the autosampler are given.
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