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  • Title: [Effects of esmolol and fentanyl on the hemodynamic and catecholamine response to tracheal intubation in hypertensive patients].
    Author: Cheng MH, Yao YM.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2003 Jul; 15(7):435-7. PubMed ID: 12857503.
    Abstract:
    OBJECTIVE: To compare effects of esmolol and fentanyl on the hemodynamic and catecholamine response to tracheal intubation in hypertensive patients. METHODS: Sixty hypertensive patients were randomly allocated into one of four groups: the patients received 0.9% saline in group A, 2 mg/kg esmolol in group B, 2 microg/kg fentanyl in group C and 2 mg/kg esmolol combined with 2 microg/kg fentanyl in group D before intubation. Tracheal intubation was performed with 0.1 mg/kg midazolam, 0.6 mg/kg atracurium and 2 mg/kg propofol. Systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), rate-pressure product (RPP), plasma noradrenaline (NA) and adrenaline (A) concentrations were measured before and after intubation. RESULTS: SAP, DAP, HR, RPP, NA and A levels in group A at 1 and 3 minutes after intubation were significantly higher than the baseline values (all P<0.01). NA levels in group B and SAP in group C increased significantly after intubation (both P<0.05). The hemodynamics and catecholamine in group D after intubation were not significantly different from the baselines (all P>0.05). CONCLUSION: 2 mg/kg esmolol or 2 microg/kg fentanyl can partly reduce hemodynamic response to intubation and 2 mg/kg esmolol combined with 2 microg/kg fentanyl can completely attenuate the hemodynamic and catecholamine response in hypertensive patients.
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